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General description
60S ribosomal protein L26 (UniProt: P61254) is encoded by the RPL26 gene (Gene ID: 6154) in human. 60S ribosomal protein L26 belongs to the ribosomal protein L24P family and is found in all eukaryotes. It is primarily localized in the cytoplasm, but to a lesser extent it is also found in the nucleoplasm and nucleolus. It associates with the large 60S subunit of the ribosome and contains a KOW motif, a conserved RNA-binding motif present in many ribosomal proteins. 60S ribosomal protein L26 is shown to be involved in translation. Knockdown of RPL26 results in a significant decrease in synthesis of 28S rRNA (associated with 60S subunit). Overexpression of RPL26 is shown to enhance the binding of p53 mRNA to the ribosomes and increase p53 translation, which subsequently leads to cell-cycle arrest at G1 phase and can enhance radiation-stimulated apoptosis. Mutations in RPL26 gene are reported to cause congenital non-regenerative hypoplastic anemia that is characterized by a moderate to severe macrocytic anemia, erythroblastopenia, and an increased risk of malignancy.
~17 kDa observed; 17.26 kDa calculated. Uncharacterized bands may be observed in some lysate(s).
Immunogen
GST-tagged recombinant fragment corresponding to the first 95 amino acids from human 60S ribosomal protein L26.
Application
Anti-60S Ribosomal Protein L26 Antibody, Cat. No. ABE1438, is a highly specific rabbit polyclonal antibody that targets 60S ribosomal protein L26 and has been tested in Immunohistochemistry (Paraffin), and Western Blotting.
Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected 60S Ribosomal Protein L26 in human cerebral cortex, human pancreas, and human colon tissues.
Research Category
Epigenetics & Nuclear Function
Biochem/physiol Actions
This polyclonal antibody detects 60S ribosomal protein L26 in human.
Physical form
Affinity Purified
Purified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Preparation Note
Stable for 1 year at 2-8°C from date of receipt.
Analysis Note
Evaluated by Western Blotting in Hek293 cell lysate.
Western Blotting Analysis: A 1:500 dilution of this antibody detected 60S Ribosomal Protein L26 in 10 µg of HEK293 cell lysate.
Other Notes
Concentration: Please refer to lot specific datasheet.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
| biological source | rabbit |
| Quality Segment | 100 |
| conjugate | unconjugated |
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone | polyclonal |
| purified by | affinity chromatography |
| species reactivity | human |
| packaging | antibody small pack of 25 μL |
| technique(s) | immunohistochemistry: suitable (paraffin),western blot: suitable |
| NCBI accession no. | NP_000978 |
| UniProt accession no. | P61254 |
| shipped in | ambient |
| target post-translational modification | unmodified |
| Gene Information | human ... RPL26(6154) |
| 长度(mm) | |
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