Anti-LGI1 Antibody,100UG,ABD136,Sigma

销售价: ¥ 2919.02 / 件
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订货号 0BV7869
品牌型号 Sigma ABD136
货期 询货期
最小订货量 1件
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产品介绍 Product Description

General description

~56 kDa observed. Uniprot describes 3 isoforms at ~33 kDa, ~58 kDa, and ~64 kDa Uncharacterized bands may appear in some lysates.
Leucine-rich glioma inactivated gene 1 (LGI1), also known as Epitempin-1 (EPT), is a member of a family of highly related proteins containing leucine-rich repeats (LRRs) regulating voltage-gated potassium channels assembled from KCNA1, KCNA4 and KCNAB1. LGI1 may play a role in the control of neuroblastoma cell survival and may play a role in other cancers. It is expressed in neural tissue, especially brain. Mutations in LGI1 have been associated with nearly half of autodominant lateral temporal epilepsy (ADTLE).


Immunogen

KLH-conjugated linear peptide corresponding to the N-terminus of human LGI1.


Application

Detect LGI1 using this rabbit polyclonal antibody, Anti-LGI1 Antibody validated for use in western blotting.


Biochem/physiol Actions

This antibody recognizes the N-terminus of LGI1.


Analysis Note

Evaluated by Western Blotting/Peptide Inhibition Assay in mouse brain tissue lysate.

Western Blotting/Peptide Inhibition Assay Analysis: 1 µg/mL of this antibody detected LGI1 in 15 µg of mouse brain tissue lysate.


Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.


技术参数 Specifications
biological sourcerabbit
Quality Segment100
conjugateunconjugated
antibody formaffinity isolated antibody
antibody product typeprimary antibodies
clonepolyclonal
purified byaffinity chromatography
species reactivitymouse
species reactivity (predicted by homology)human (immunogen homology)
technique(s)western blot: suitable
UniProt accession no.O95970
shipped inwet ice
target post-translational modificationunmodified
Gene Informationhuman ... LGI1(9211)
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