Anti-CD115 (c-fms) Antibody (mouse), PE, clone AFS98，100UG，MABF509，Sigma 供应商、价格、厂家、报价、规格参数

产品介绍 Product Description

General description

The AFS98 antibody is specific for mouse CD115, also known as Colony-Stimulating Factor-1 Receptor (CSF-1R), a 145 kDa receptor from the PDGF receptor family. Receptor activation by the ligands IL-34 or CSF-1 (M-CSF) occurs via homodimerization of CD115 and subsequent tyrosine phosphorylation and ubiquitination of intracellular domains. CD115 signaling promotes differentiation of myeloid precursors, as well as the continued regulation of proliferation, survival and function of mononuclear phagocytes, dendritic cells and osteoclasts. While IL-34 and CSF-1 may induce similar cellular responses, they are differentially expressed and as such exert complimentary actions via CD115.The AFS98 antibody may be used for identification of myeloid lineage cells by flow cytometry, and is commonly used for in vivo or in vitro neutralization of CSF-1 Receptor.
This rat monoclonal antibody Anti-CD115 (c-fms) (mouse), PE, clone AFS98 validated for use in western blotting & Flow Cytometry for the detection of CD115 (c-fms).

Analysis Note

The monoclonal antibody was purified from tissue culture supernatant via affinity chromatography. The purified antibody was conjugated under optimal conditions, with unreacted dye removed from the preparation.

Flow Cytometry Analysis: 0.125 µg of this antibody detected CD115 (c-fms) in one million C57Bl/6 peripheral blood cells.

技术参数 Specifications

biological source	rat
Quality Segment	100
conjugate	PE
antibody form	purified antibody
antibody product type	primary antibodies
clone	AFS98, monoclonal
species reactivity	mouse
concentration	0.2 mg/mL
technique(s)	flow cytometry: suitable,western blot: suitable
isotype	IgG2aκ
UniProt accession no.	P09581
shipped in	wet ice
target post-translational modification	unmodified
Gene Information	mouse ... Csf1R(12978)

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