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Anti-CD274 (PD-L1) Antibody (mouse), PE, clone 10F-9G2，100UG，MABF404，Sigma

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订货号： 0BV8443

品牌型号： Sigma MABF404

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最小订货量： 1件

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商品介绍
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包装参数

产品介绍 Product Description

General description

The 10F.9G2 antibody is specific for mouse CD274, more commonly known as PD-L1 or B7-H1, which acts as a ligand for the T cell co-regulatory receptor PD-1 (CD279). This interaction modulates T cell antigen receptor (TCR) signaling and therefore T cell activation. PD-L1 binding to PD-1 expressed on CD4- CD8- thymocytes participates in the processes of clonal selection, elimination of autoreactive lymphocytes, and development of tolerance. PD-L1 may also bind PD-1 following the receptor’s inducible expression on activated, mature T cells, where it has been proposed to limit T cell activation. PD-L1 is one of a group of “B7” ligands whose interactions with the CD28 receptor family, also including CTLA-4 (CD152), provide a balance of co-stimulatory /co-inhibitory signaling important in T cell activation, tolerance, and autoimmunity.The 10F.9G2 antibody may be used as a marker for PD-L1 expression on T and B cells, NK cells and on dendritic cells. It is also widely used for analysis of receptor-ligand interaction and function(s) in vitro and in vivo.

Immunogen

Immunogen information for this antibody is proprietary information.

Application

Research Category
Inflammation & Immunology
This rat monoclonal antibody Anti-CD274 (PD-L1) (mouse), PE & clone 10F-9G2 validated for use in Flow Cytometry for the detection of CD274 (PD-L1).

Physical form

Purified Rat Monoclonal Antibody in buffer containing 10 mM NaH2PO4, 150 mM NaCl, 0.1% gelatin, pH 7.2, and up to 0.1% sodium azide.
Size Exclusion Chromatography

Preparation Note

It is recommended to store the product undiluted at 2-8°C and protected from prolonged exposure to light. Do not freeze.

Analysis Note

The monoclonal antibody was purified from tissue culture supernatant via affinity chromatography. The purified antibody was conjugated under optimal conditions, with unreacted dye removed from the preparation.

Flow Cytometry Analysis: 0.25 µg of this antibody detected CD274 (PD-L1) in one million C57Bl/6 splenocytes.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

技术参数 Specifications

biological source	rat
Quality Segment	100
conjugate	PE
antibody form	purified antibody
antibody product type	primary antibodies
clone	10F.9G2, monoclonal
species reactivity	mouse
concentration	0.2 mg/mL
technique(s)	flow cytometry: suitable
isotype	IgG2bκ
UniProt accession no.	Q9EP73
shipped in	wet ice
target post-translational modification	unmodified
Gene Information	mouse ... Cd274(60533)

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