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General description
Metastasis suppressor protein 1 (UniProt O43312; also known as Metastasis suppressor YGL-1, Missing in metastasis protein) is encoded by the MTSS1 (also known as KIAA0429, MIM) gene (Gene ID 9788) in human. MTSS1 is a scaffold protein that regulates cytoskeletal dynamics and actin polymerization. MTSS1 is also reported to bind Gli proteins or the Gli-Sufu complex and potentiate the transcription of effector genes of the sonic hedgehog signaling pathway. MTSS1 is down-regulated in many metastatic cancer cells compared with their non-metastatic counterparts. MTSS1 expression is shown to be inversely correlated with the prognosis of solid carcinomas of the breast, liver, and bladder.
~82 kDa observed
Immunogen
Epitope: C-terminal
GST-tagged recombinant protein corresponding to the C-terminal of human MTSS1.
Application
Detect MTSS1 using this mouse monoclonal Anti-MTSS1 Antibody, clone 15C3.2, Cat. No. MABC607, validated for use in Western Blotting and Immunohistochemistry (Paraffin).
Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected MTSS1 in human colon and human spleen tissues.
Research Category
Apoptosis & Cancer
Research Sub Category
Apoptosis - Additional
Biochem/physiol Actions
This clone is expected to react with all 4 spliced isoforms of human MTSS1.
Physical form
Format: Purified
Protein G Purified
Purified mouse monoclonal IgG2aκ antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Preparation Note
Stable for 1 year at 2-8°C from date of receipt.
Analysis Note
Evaluated by Western Blotting in COS-1 cell lysate.
Western Blotting Analysis: 0.5 µg/mL of this antibody detected MTSS1 in 10 µg of COS-1 cell lysate.
Other Notes
Concentration: Please refer to lot specific datasheet.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
| biological source | mouse |
| Quality Segment | 100 |
| conjugate | unconjugated |
| antibody form | purified immunoglobulin |
| antibody product type | primary antibodies |
| clone | 15C3.2, monoclonal |
| species reactivity | monkey, human |
| technique(s) | immunohistochemistry: suitable (paraffin),western blot: suitable |
| isotype | IgG2aκ |
| NCBI accession no. | NP_055566 |
| UniProt accession no. | O43312 |
| shipped in | wet ice |
| target post-translational modification | unmodified |
| Gene Information | human ... MTSS1(9788) |
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