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Anti-FoxP2 Antibody，100UL，ABE73，Sigma

销售价： ¥ 4406.83 / 件

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订货号： 0BV8600

品牌型号： Sigma ABE73

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最小订货量： 1件

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商品介绍
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产品介绍 Product Description

General description

80 and 77 kDa Observed. Alternative splicing can result in cell type dependent isoforms.
Forkhead box protein P2 (FoxP2) is a multidomain transcriptional repressor that belongs to the Fox family of proteins. The FoxP2 protein contains a forkhead-box DNA-binding domain, characteristic of the FOX group of transcription factors. In addition, this protein contains a polyglutamine tract, as well as zinc finger and leucine zipper motifs. In order for FoxP2 to bind DNA, it forms homodimers and heterodimers with FoxP1 and FoxP4.
The forkhead box family of proteins play an important role in immune response, organ development and the development of cancer. Functional studies in vertebrates suggest this with this gene plays a role in the modulation neural plasticity. In line with these findings, mutations of FoxP2 in humans have been linked to speech and language disorders.

Immunogen

Epitope: Unknown
GST-tagged recombinant protein corresponding to mouse FoxP2.

Application

Anti-FoxP2 Antibody is a Rabbit Polyclonal Antibody for detection of FoxP2 also known as forkhead box P2, trinucleotide repeat containing 10 & has been validated in WB & IHC.
Research Category
Epigenetics & Nuclear Function

Neuroscience
Research Sub Category
Transcription Factors

Neurodegenerative Diseases
Western Blot Analysis: 1:1,000 dilution from a representative lot detected FoxP2 in 10 µg of L6, NIH/3T3, mouse brain, rat brain, and human brain lysates.

Immunohistochemistry Analysis: A representative lot was used by an independent laboratory in IH. (Lu, M.M., et al. (2002). Mechanisms of Development 119S:S197–S202.)

Biochem/physiol Actions

This antibody recognizes FoxP2.

Physical form

Unpurified
Unpurified rabbit polyclonal serum with 0.05% sodium azide.

Preparation Note

Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.

Analysis Note

Control
RAW264.7 cell lysate
Evaluated by Western Blot in RAW264.7 cell lysate.

Western Blot Analysis: 1:1,000 dilution of this antibody detected FoxP2 on 10 µg of RAW264.7 cell lysate.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

技术参数 Specifications

biological source	rabbit
Quality Segment	100
conjugate	unconjugated
antibody form	serum
antibody product type	primary antibodies
clone	polyclonal
species reactivity	rabbit, human, mouse
technique(s)	immunohistochemistry: suitable,western blot: suitable
isotype	IgG
NCBI accession no.	NP_444472
UniProt accession no.	P58463
shipped in	wet ice
target post-translational modification	unmodified
Gene Information	human ... FOXP2(93986) mouse ... Foxp2(114142)

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