Protein Synthesis Initiation Inhibitor, NSC 119889,25MG,539690-25MGCN,Sigma

销售价: ¥ 3220.08 / 件
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订货号 0BV8662
品牌型号 Sigma 539690-25MGCN
货期 询货期
最小订货量 1件
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产品介绍 Product Description

General description

A cell-permeable, xanthenyl compound that prevents mRNA-ribosome interaction and inhibits 5’-mediated/cap-dependent initiation of protein synthesis (>95% inhibition at 50 µM in in vitro translation assays using Krebs, rabbit reticulocyte, or E. coli S30 extract).


Biochem/physiol Actions

Cell permeable: yes
Primary Target
human arginine methyl transferase
Product does not compete with ATP.
Reversible: no
Target IC50: 1.41 µM against human arginine methyl transferase


Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.


Other Notes

Novac, O., et al. 2004. Nucleic Acids Res.32, 902.
Tan, Y.J., et al. 2003. J. Cancer Res. Clin. Oncol.129, 437.


Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany


Disclaimer

Toxicity: Irritant (B)


技术参数 Specifications
Quality Level100
assay≥95% (HPLC)
formsolid
manufacturer/tradenameCalbiochem®
storage conditionOK to freeze,protect from light
colorlight brown
solubilityDMSO: 200 mg/mL,methanol: soluble
shipped inambient
storage temp.2-8°C
长度(mm)
宽度(mm)
高度(mm)
重量(kg)
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