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General description
Zinc finger MYM-type protein 2 (UniProt: Q9UBW7; also known as Fused in myeloproliferative disorders protein; Rearranged in atypical myeloproliferative disorder protein; Zinc finger protein 198) is encoded by the ZMYM2 (also known as FIM, RAMP, ZNF198) gene (Gene ID: 7750) in human. Zinc finger MYM-type protein 2 is a nuclear protein that may function as a transcription factor. Two isoforms of Zinc finger MYM-type protein 2 have been described that are produced by alternative splicing. The SUMO-interacting motifs (SIM) of Zinc finger MYM-type protein 2 are shown to be essential for its recruitment to chromatin. The SIM motifs play an important role in its gene-regulatory activities, however, they are not required for the intrinsic transcriptional repressive properties of Zinc finger MYM-type protein 2. A chromosomal aberration involving ZMYM2 is reported to cause stem cell leukemia lymphoma syndrome (SCLL), which is characterized as lymphoblastic lymphoma in association with a myeloproliferative disorder accompanied by pronounced peripheral eosinophilia and/or prominent eosinophilic infiltrates in the affected bone marrow. (Ref.: Aguilar-Martinez, E., et al. (2015). Proc. Natl. Acad. Sci. USA. 112 (35); E4854-E4863).
~155 kDa observed; 154.91 kDa calculated. Uncharacterized bands may be observed in some lysate(s).
Immunogen
GST/His-tagged recombinant fragment corresponding to 167 amino acids from the C-terminal region of human Zinc finger MYM-type protein 2.
Application
Anti-ZMYM2, clone 9F12.1, Cat. No. MABN2263, is a highly specific mouse monoclonal antibody that targets Zinc finger MYM-type protein 2 and has been tested in Western Blotting.
Biochem/physiol Actions
Clone 9F12.1 detects Zinc finger MYM-type protein 2 in human cells. It targets an epitope within 167 amino acids from the C-teminal region.
Physical form
Format: Purified
Analysis Note
Evaluated by Western Blotting in human hippocampus tissue lysate.
Western Blotting Analysis: 0.5 µg/mL of this antibody detected ZMYM2 in human hippocampus tissue lysate.
Other Notes
Concentration: Please refer to lot specific datasheet.
| biological source | mouse |
| Quality Level | 100 |
| conjugate | unconjugated |
| antibody form | purified antibody |
| antibody product type | primary antibodies |
| clone | 9F12.1, monoclonal |
| species reactivity | human |
| packaging | antibody small pack of 25 μg |
| technique(s) | western blot: suitable |
| isotype | IgG2aκ |
| NCBI accession no. | NP_001177893 |
| UniProt accession no. | Q9UBW7 |
| shipped in | ambient |
| target post-translational modification | unmodified |
| Gene Information | human ... ZMYM2(7750) |
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