- 商品介绍
- 规格参数
- 包装参数
General description
A cell-permeable, potent, and selective MDM2 antagonist (IC50 = 90 nM for Nutlin-3a and 13.6 µM for Nutlin-3b) that displays antitumor properties. Activates the p53 pathway by binding MDM2 in the p53-binding pocket and inhibiting the MDM2-p53 interaction. Shown to induce apoptosis in several cancer cell lines with wild-type p53 and in xenografted tumor mice.
Packaging
Packaged under inert gas
Physical form
A 10 mM (1 mg/172 µl) solution of MDM2 Antagonist, Nutlin-3, Racemic (Cat. No. 444143) in DMSO
Preparation Note
Following initial thaw, aliquot and freeze (-20°C).
Other Notes
Thompson, T., et al. 2004. J. Biol. Chem.279, 53015.
Vassilev, L.T., et al. 2004. Science303, 844.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Irritant (B)
| Quality Level | 100 |
| assay | ≥98% (HPLC) |
| form | liquid |
| manufacturer/tradename | Calbiochem® |
| storage condition | OK to freeze,desiccated (hygroscopic),protect from light |
| shipped in | wet ice |
| storage temp. | −20°C |
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¥ 1259.40
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¥ 1563.36
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¥ 1779.22
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¥ 8293.41
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¥ 238.17
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¥ 2151.46
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¥ 1749.15
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¥ 745.60
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¥ 1196.14
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¥ 787.34
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¥ 1586.69
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¥ 4614.63
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¥ 64659.66
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