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General description
The TRK-fused gene protein (TFG) gene is highly conserved among mammalian species, and is widely studied as a fusion gene partnering with various oncogenes. The function of the resultant TFG protein product is still unclear. TFG regulates the activity of phosphotyrosine-specific phosphatase-1 (SHP-1), and may be important in cells containing SHP-1 such as epithelial and neuronal cells. Defective TFG contributes to thyroid papillary carcinoma.
~56 kDa observed. The calculated molecular weight is 43 kDa, however TFG has been shown as a ~56 kDa band in western blots (Greco, A., et al. (1995). Molecular and Cellular Biology. 15(11):6118–6127.)
Immunogen
Epitope: C-terminus
KLH-conjugated linear peptide corresponding to the C-terminus of human TFG.
Application
Research Category
Neuroscience
Research Sub Category
Developmental Neuroscience
This Anti-TFG Antibody is validated for use in Western Blotting, IHC(P) for the detection of TFG.
Western Blot Analysis: 0.1 µg/mL from a representative lot detected TFG on 10 µg of human brain tissue lysate.
Immunohistochemistry Analysis: A 1:1,000 dilution from a representative lot detected TFG in mouse hippocampus, mouse cerebellum, human placenta, and human pancreas tissues.
Biochem/physiol Actions
This antibody recognizes the C-terminus of TFG.
Physical form
Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Format: Purified
Protein A purified
Preparation Note
Stable for 1 year at 2-8°C from date of receipt.
Analysis Note
Control
HeLa cell lysate
Evaluated by Western Blot in HeLa cell lysate.
Western Blot Analysis: 0.1 µg/mL of this antibody detected TFG on 10 µg of HeLa cell lysate.
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
| biological source | rabbit |
| Quality Segment | 100 |
| conjugate | unconjugated |
| antibody form | purified antibody |
| antibody product type | primary antibodies |
| clone | polyclonal |
| species reactivity | rat, mouse, human |
| technique(s) | immunohistochemistry: suitable (paraffin),western blot: suitable |
| NCBI accession no. | NP_001007566 |
| UniProt accession no. | Q92734 |
| shipped in | wet ice |
| target post-translational modification | unmodified |
| Gene Information | human ... TFG(10342) |
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