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General description
Increasing drug candidate predictability earlier in the discovery pipeline using non-cell-based assays can improve candidate throughput during the ADME stage. Non-cell-based permeability assays are predictive models for oral absorption of development candidates.
MultiScreen Permeability, MultiScreen-IP, and MultiScreen Acceptor plates support artificial membrane strategies for predicting passive transport.
Membranes have uniform pore structure and density for reliable transport:
- Individual wells minimize candidate cross-talk
- Compatibility with automated liquid handling systems increases throughput
Permeability Assay:
- The MultiScreen Permeability plate has a polycarbonate membrane, which supports a hexane/hexadecane artificial layer for permeability assays.1
PAMPA Assay:
- The MultiScreen-IP plate has a hydrophobic PVDF membrane, which supports a lipid bilayer for PAMPA asays.2,3
MultiScreen Acceptor Plate:
- The MultiScreen Acceptor plate can be used with either plate to capture passively transported compounds. Constructed of 100% PTFE, the plate can improve LC/MS results depending on the charge of the small molecules being evaluated.
Application
Non-Sterile, reusable, sturdy device made of PTFE, acceptor plate for PAMPA assays, 1 plate
Research Category
Nucleic acid|Protein
Physical form
Color Code:Not Applicable
Other Notes
Automation Compatible:Yes
Legal Information
MULTISCREEN is a registered trademark of Merck KGaA, Darmstadt, Germany
| material | PTFE plate (PTFE),white plate |
| sterility | non-sterile |
| usage | Manual |
| packaging | pkg of 1 collection plate |
| manufacturer/tradename | MultiScreen® |
| technique(s) | parallel artificial membrane permeation assay (PAMPA): suitable |
| plate size | 96 wells |
| compatibility | manifold only |
| 长度(mm) | |
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| 重量(kg) |
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¥ 1148.92
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¥ 2013.69
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¥ 1724.25
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¥ 4390.38
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¥ 3812.28
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¥ 15214.65
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¥ 4011.97
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¥ 2099.27
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¥ 3662.39
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¥ 56581.65
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¥ 70526.15
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