- 商品介绍
- 规格参数
- 包装参数
General description
Mucin-16 (UniProt: Q8WXI7; also known as MUC-16, Ovarian cancer-related tumor marker CA125, CA-125, Ovarian carcinoma antigen CA125) is encoded by the MUC16 (also known as CA125) gene (Gene ID: 94025) in human. Mucin-16 is a heavily O-glycosylated protein that can be liberated into the extracellular space following the phosphorylation of the intracellular C-terminus, which induces proteolytic cleavage and liberation of extracellular domain. I provides protective, lubricating barrier against particles and infectious agents at mucosal surfaces. Mucin-16 is composed of three domains: a Serine, Threonine-rich N-terminal domain, a repeated domain containing between 12 and 60 partially conserved tandem repeats of 156 amino acids and a C-terminal transmembrane domain with a short cytoplasmic tail. Its expression is up-regulated in ovarian cancer cells and may serve as a marker for ovarian cancer. Mucin-16 is shown to binds to mesothelin (MSLN) and this binding mediates heterotypic cell adhesion, which may contribute to the metastasis of ovarian cancer to the peritoneum by initiating cell attachment to the mesothelial epithelium.
1519.17 kDa calculated.
Physical form
Format: Purified
Analysis Note
Evaluated by Immunohistochemistry in human ovarian cancer and human uterine tissues.
Immunohistochemistry (Paraffin) Analysis: A 1:50-250 dilution of this antibody detected Mucin-16 in human ovarian cancer and human uterine tissues.
Other Notes
Concentration: Please refer to lot specific datasheet.
| biological source | mouse |
| Quality Level | 100 |
| conjugate | unconjugated |
| antibody form | purified antibody |
| antibody product type | primary antibodies |
| clone | monoclonal |
| species reactivity | human |
| technique(s) | immunohistochemistry: suitable (paraffin),proximity ligation assay: suitable,western blot: suitable |
| isotype | IgG1κ |
| NCBI accession no. | NP_078966.2 |
| UniProt accession no. | Q8WXI7 |
| shipped in | ambient |
| target post-translational modification | unmodified |
| Gene Information | human ... MUC16(94025) |
| 长度(mm) | |
| 宽度(mm) | |
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| 重量(kg) |
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NNALGENE 180透明塑料管，透明，柔软，多用，经济，内径 x 外径x壁厚，1/4 x 1/2 x 1/8，英寸，每箱数量50，50/箱，8000-0080，Thermofisher，赛默飞世尔询价
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