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General description
Ras-related protein Rab-7A (Rab7A, RAB7) is a small intracellular protein typically associated with cytoplasmic vesicles, phagosomes, and endosomes and is expressed in most cells but particularly high in muscle. It plays an important role in regulating the endo-lysosomal trafficking of proteins as well as in the endosomal trapping of pathogens and viruses. Besides endosome-lysosome trafficking, Rab7A functions in a variety of other critical cellular processes including nutrient uptake, growth factor mediated growth, neurotrophin transport, lipid transport, lysosome and phagosome maturation and development, as well as pathogen and virus innate immunity functions. RAB7A interacts with a number of other proteins within the cell, some important in endosome trafficking like RILP (Rab-interacting lysosomal protein) and CHM (Rab escort protein 1) others like RAC1 have a more pleiotropic impact and are part of many cellular processes, including the cell cycle, cell-cell adhesion, cytoskeletal motility, and cellular differentiation.
~23 kDa observed
Immunogen
GST-tagged recombinant protein corresponding to human Rab7A.
Application
Detect Rab7A using this Anti-Rab7A antibody, clone 5G8.1 validated for use in western blotting & IHC.
Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected Rab7A in human breast cancer and human cardiac myocytes and lymphocytes in human heart tissue.
Research Category
Apoptosis & Cancer
Research Sub Category
Apoptosis - Additional
Physical form
Format: Purified
Protein G Purified
Purified mouse monoclonal IgG2bκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Preparation Note
Stable for 1 year at 2-8°C from date of receipt.
Analysis Note
Evaluated by Western Blotting in SK-MEL28 cell lysate.
Western Blotting Analysis: A 1:2,000 dilution of this antibody detected Rab7A in 10 µg of SK-MEL28 cell lysate.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
| biological source | mouse |
| Quality Segment | 100 |
| conjugate | unconjugated |
| antibody form | purified immunoglobulin |
| antibody product type | primary antibodies |
| clone | 5G8.1, monoclonal |
| species reactivity | human |
| concentration | 0.5 mg/mL |
| technique(s) | immunohistochemistry: suitable,western blot: suitable |
| isotype | IgG2bκ |
| NCBI accession no. | NP_004628 |
| UniProt accession no. | P51149 |
| shipped in | wet ice |
| target post-translational modification | unmodified |
| Gene Information | human ... RAB7A(7879) |
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