- 商品介绍
- 规格参数
- 包装参数
General description
Sprouty-related, EVH1 domain-containing protein 1 (SPRED1) is a tyrosine kinase substrate which has a cysteine-rich domain which resembles the SPR domain at the carboxy terminus. SPRED1 associated with Ras blocks phosphorylation of Raf and disrupts MAP kinase signaling during the differentiation of neuronal cells and myocytes. A mutation in SPRED1 has been linked to Lugius syndrome, an autosomal dominant RAS-MAPK pathway syndrome.
~ 60 kDa observed
Immunogen
Linear peptide corresponding to human Spred-1.
Application
Detect Spred-1 using this mouse monoclonal antibody, Anti-Spred-1 Antibody, clone M23-P2G3 validated for use in western blotting & ICC.
Immunocytochemistry Analysis: A representative lot detected Spred-1 in HeLa cells.
Research Category
Neuroscience
Research Sub Category
Developmental Signaling
Physical form
Protein G Purified
Purified mouse monoclonal IgG1λ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Preparation Note
Stable for 1 year at 2-8°C from date of receipt.
Analysis Note
Evaluated by Western Blotting in mouse brain tissue lysate.
Western Blotting Analysis: 1.0 µg/mL of this antibody detected Spred-1 in 10 µg of mouse brain tissue lysate.
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
| biological source | mouse |
| Quality Segment | 100 |
| conjugate | unconjugated |
| antibody form | purified antibody |
| antibody product type | primary antibodies |
| clone | M23-P2G3, monoclonal |
| purified by | affinity chromatography |
| species reactivity | rat, mouse |
| species reactivity (predicted by homology) | human (based on 100% sequence homology) |
| technique(s) | immunocytochemistry: suitable,western blot: suitable |
| isotype | IgG1λ |
| NCBI accession no. | NP_689807 |
| UniProt accession no. | Q7Z699 |
| shipped in | wet ice |
| target post-translational modification | unmodified |
| Gene Information | human ... SPRED1(161742) |
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