MMP Inhibitor I,10MG,444250-10MGCN,Sigma

销售价: ¥ 2072.18 / 件
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订货号 0BW0771
品牌型号 Sigma 444250-10MGCN
货期 询货期
最小订货量 1件
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产品介绍 Product Description

General description

A tetrapeptidyl hydroxamic acid that inhibits interstitial and granulocyte collagenases (MMP-1 and MMP-8; IC50 = 1 µM), granulocyte gelatinase (MMP-9; IC50 = 30 µM), adn skin fibroblast stromelysin (MMP-3; IC50 = 150 µM). Retains its activity even after prolonged incubation with PRONASE Protease (Cat. No. 53702) or human neutrophil elastase.


Biochem/physiol Actions

Cell permeable: no
Primary Target
MMP-1, MMP-8
Product does not compete with ATP.
Reversible: no


Preparation Note

Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.


Other Notes

4-Abz-Gly-Pro-D-Leu-D-Ala-NH-OH [Abz = aminobenzoyl]
Hagemamn, T., et al. 2004. Carcinogenesis25, 1543.
Odake, S., et al. 1994. Biochem. Biophys. Res. Commun. 199, 1442.


Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany


Disclaimer

Toxicity: Standard Handling (A)


技术参数 Specifications
Quality Segment100
assay≥95% (HPLC)
formsolid
potency1 μM IC50
manufacturer/tradenameCalbiochem®
storage conditionOK to freeze
color white
solubilitywater: 1 mg/mL
shipped inambient
storage temp.−20°C
长度(mm)
宽度(mm)
高度(mm)
重量(kg)
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