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General description
Myostatin, also known as Growth/differentiation factor 8, is a negative regulator of skeletal muscle growth encoded by the MSTN (also known as MSLHP and GDF8) gene in human. Myostatin is a member of the bone morphogenetic protein (BMP) family within the TGF-ß superfamily. Growth and differentation factor-associated serum protein-1 & 2 (GASP-1/2) and follistatin-related gene (FLRG) protein are reported to interact with myostatin and negatively regulate its activity (PMID 24019467, 17878677). Mutation in MSTN gene is known to cause muscle hypertrophy (MSLHP), a condition characterized by increased muscle bulk and strength.
~31 kDa observed. 30–32 kDa band assumed to be a glycosylated dimer of the carboxy terminus portion of the full length translational product (Artaza, J.N., et al. (2007). J. of Endocrinology. 194:63-76). This antibody also detected the 32-kDa band corresponding to the processed dimer (Artaza, J.N., et al. (2007). J. of Endocrinology. 146(8):3547-3557).
Immunogen
Epitope: Near C-terminal
KLH-conjugated linear peptide corresponding to human Myostatin near the C-terminal.
Application
Anti-Myostatin Antibody, Near CT is an antibody against Myostatin, Near CT for use in Western Blotting and Immunohistochemistry.
Immunohistochemistry Analysis: A 1:50-1,000 dilution from a representative lot detected Myostatin in human cardiac myocytes tissue.
Research Category
Signaling
Research Sub Category
Signaling Neuroscience
Physical form
Affinity
Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Preparation Note
Stable for 1 year at 2-8°C from date of receipt.
Analysis Note
Evaluated by Western Blotting in human adult heart tissue lysate.
Western Blotting Analysis: 1.0 µg/mL of this antibody detected Myostatin in 10 µg of human adult heart tissue lysate.
Other Notes
Concentration: Please refer to lot specific datasheet.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
| biological source | rabbit |
| Quality Level | 100 |
| conjugate | unconjugated |
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone | polyclonal |
| purified by | affinity chromatography |
| species reactivity | human |
| species reactivity (predicted by homology) | primate (based on 100% sequence homology), rat (based on 100% sequence homology), mouse (based on 100% sequence homology), monkey (based on 100% sequence homology), chimpanzee (based on 100% sequence homology) |
| technique(s) | immunohistochemistry: suitable,western blot: suitable |
| NCBI accession no. | NP_005250 |
| UniProt accession no. | O14793 |
| shipped in | wet ice |
| target post-translational modification | unmodified |
| Gene Information | human ... MSTN(2660) |
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