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General description
Research area: Cell signaling
Application
PARG human has been used in the digestion of sciatic nerve sections, in co-immunoprecipitation, in in vitro glycohydrolase activity assay
Biochem/physiol Actions
Poly(ADP-ribose) glycohydrolase(PARG) hydrolyzes poly(ADP-ribose) at glycosidic(1′′-2′′) linkage of ribose-ribose bond to produce free ADP-ribose. It is an endo- and exo-glycosidase. PARG plays arole in DNA repair and replication. Inhibited or depleted PARG in cells aremore prone to DNA-damaging agents. PARG also averts the accumulation of PAR inthe cytoplasm and parthanatos, a caspase-independent PAR-mediated type of celldeath.
Physical form
Solution in 50 mM TRIS-HCl, pH 7.5, containing 100 mM sodium chloride, 0.2% NP-40, 50 mM imidazole and 10% glycerol.
Other Notes
Human PARG is fused to a His-tag.
| biological source | human |
| recombinant | expressed in Sf21 cells |
| tag | His tagged |
| assay | >95% (SDS-PAGE) |
| form | liquid |
| mol wt | ~110 kDa by SDS-PAGE |
| packaging | pkg of 2 μg |
| concentration | ≥0.2 mg/mL |
| technique(s) | cell based assay: suitable |
| color | clear |
| solubility | water: soluble |
| UniProt accession no. | Q86W56 |
| shipped in | dry ice |
| storage temp. | −70°C |
| Gene Information | human ... PARG(8505) |
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