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General description
Contactin-associated protein-like 2 (UniProt: Q9UHC6; also known as Cell recognition molecule Caspr2, CNTNAP2) is encoded by the CNTNAP2 (also known as CASPR2, KIAA0868) gene (Gene ID: 26047) in human. CNTNAP2 is a single-pass type I membrane glycoprotein protein of the neurexin family that is predominantly expressed in the nervous system. It mediates synaptic cell adhesion and is required, with CNTNAP1, for radial and longitudinal organization of myelinated axons. It also plays a role in the formation of functional distinct domains that are critical for saltatory conduction of nerve impulses in myelinated nerve fibers. CNTNAP2 is synthesized with a signal peptide (aa 1-27), which is subsequently cleaved off to generate the mature form that contains an extracellular domain (aa 28-1262), a transmembrane domain (aa 1263-1283), and a cytoplasmic domain (aa 1284-1331). Knockdown of CNTNAP2 in cortical cultures is shown to impair the development of spines. Mutations in CNTNAP2 gene are known to be associated with intellectual disability, epilepsy, schizophrenia, language disorders, and autism. This ZooMAb® recombinant monoclonal antibody, generated by our propriety technology, offers significantly enhanced specificity, affinity, reproducibility, and stability over conventional monoclonals. (Ref.: Gdalyahu A, et al., (2015). PLoS ONE. 10(5); e0125633).
We are committed to bringing you greener alternative products, which adhere to one or more of The 12 Principles of Green Chemistry.This antibody is Preservative-free, produced without the harm or sacrifice of animals and exceptionally stable to allow for ambient shipping and storage if needed and thus aligns with "Waste Prevention", "Designing Safer Chemicals" and "Design for Energy Efficiency". Click here for more information.
ZooMAb antibodies represent an entirely new generation of recombinant monoclonal antibodies.
Each ZooMAb antibody is manufactured using our proprietary recombinant expression system, purified to homogeneity, and precisely dispensed to produce robust and highly reproducible lot-to-lot consistency. Only top-performing clones are released for use by researchers. Each antibody is validated for high specificity and affinity across multiple applications, including its most commonly used application. ZooMAb antibodies are reliably available and ready to ship when you need them.
Immunogen
KLH-conjugated linear peptide corresponding to 17 amino acids from the C-terminal region of human Contactin-associated protein-like 2 (CNTNAP2).
Application
Quality Control Testing
Evaluated by Western Blotting in Rat brain tissue lysate.
Western Blotting Analysis: A 1:1,000 dilution of this antibody detected CNTNAP2 in Rat brain tissue lysate.
Tested Applications
Western Blotting Analysis: A 1:1,000 dilution from a representative lot detected CNTNAP2 in Human brain tissue lysate.
Affinity Binding Assay:: A representative lot of this antibody bound CNTNAP2 peptide with a KD of 3.7 x 10-8 in an affinity binding assay.
Immunohistochemistry (Paraffin) Analysis: A 1:100 dilution from a representative lot detected CNTNAP2 in human cerebral cortex tissue sections.
Note: Actual optimal working dilutions must be determined by end user as specimens, and experimental conditions may vary with the end user
Anti-CNTNAP2, clone 2D17 ZooMAb®, Cat. No. ZRB1079, is a rabbit recombinant monoclonal antibody that specifically targets CNTNAP2 and is tested for use in Affinity Binding Assay, Immunohistochemistry, and Western Blotting.
Biochem/physiol Actions
Clone 2D17 is a ZooMAb® rabbit recombinant monoclonal antibody that specifically detects Contactin-associated protein-like 2 (CNTNAP2). It targets an epitope within 17 amino acids from the C-terminal, cytoplasmic domain.
Physical form
Purified recombinant mouse monoclonal antibody IgG, lyophilized in PBS, 5% Trehalose, normal appearance a coarse or translucent resin. Contains no biocide or preservatives, such as azide, or any animal by-products. Larger pack sizes provided as multiples of 25 μL.
Preparation Note
Recommend storage of lyophilized product at 2-8°C; Before reconstitution, micro-centrifuge vials briefly to spin down material to bottom of the vial; Reconstitute each vial by adding 25 μL of filtered lab grade water or PBS; Reconstituted antibodies can be stored at 2-8°C, or -20°C for long term storage. Avoid repeated freeze-thaws.
Reconstitute lyophilized antibody pellet with 25μL of ultrapure water or Phosphate Buffered Saline (PBS). Please refer to our reconstitution protocol and the specific application guidance on the suggested starting dilutions and sample type.
Legal Information
ZooMAb is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
| biological source | rabbit |
| Quality Level | 200 |
| recombinant | expressed in HEK 293 cells |
| conjugate | unconjugated |
| antibody form | purified antibody |
| antibody product type | primary antibodies |
| clone | 2D17, recombinant monoclonal,monoclonal |
| product line | ZooMAb® learn more |
| form | lyophilized |
| mol wt | calculated mol wt ~148.17 kDa,observed mol wt ~165 kDa |
| species reactivity | rat, human |
| species reactivity (predicted by homology) | mouse, monkey |
| packaging | antibody small pack of 25 μL |
| greener alternative product characteristics | Waste Prevention Designing Safer Chemicals Design for Energy Efficiency Learn more about the Principles of Green Chemistry. |
| enhanced validation | recombinant expression Learn more about Antibody Enhanced Validation |
| sustainability | Greener Alternative Product |
| technique(s) | affinity binding assay: suitable,immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable,western blot: suitable |
| isotype | IgG |
| UniProt accession no. | Q9UHC6 |
| greener alternative category | Aligned, |
| shipped in | ambient |
| storage temp. | 2-8°C |
| target post-translational modification | unmodified |
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