AH6809，5MG，A1221-5MG，Sigma

Application

AH6809 has been used:

• as a prostaglandin E2 receptor 1 & 2 (EP1/2) antagonist to analyze its effects on cyclooxygenase-2 /prostaglandin E2 (COX-2/PGE2) signaling in the angiogenic feedback of endothelial cells to hypoxia
• as an EP2 antagonist to study its effects on tumor angiogenesis in human prostate cancer cell lines
• as an EP2 antagonist to analyze its effects on overexpression of amyloid precursor protein (APP)

Biochem/physiol Actions

AH6809 plays a role in antagonizing the proliferation of non-small cell lung cancer cell lines.
DP/EP prostanoid receptor antagonist; has the highest affinity for DP receptors, but also acts as a weak antagonist at murine EP₁ and EP₂ prostanoid receptors.

Features and Benefits

This compound is featured on the Prostanoid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.