- 商品介绍
- 规格参数
- 包装参数
Application
GGTI 298 trifluoroacetate salt hydrate has been used as a geranylgeranyltransferase I (GGTase I) inhibitor:
- to study the anticancer effects of statins along with GGTI 298
- to study its combinatorial effects with FTI-277 on statin-mediated activation of extracellular signal-regulated kinase 5 (ERK5) in the human endothelium
- to evaluate the effect of protein geranylgeranylation (GG) inhibition on the breast cancer stem cell (CSC) population
Biochem/physiol Actions
GGTI 298 is a cell-permeable, prodrug form of the geranylgeranyltransferase I (GGTase I) inhibitor GGTI-297. It inhibits the processing of Rap 1A without effecting the processing of H-Ras.
Features and Benefits
This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
| Quality Level | 100 |
| assay | ≥90% (HPLC) |
| form | film,lyophilized |
| impurities | <10% dimer |
| color | colorless |
| mp | 99.5-100 °C |
| solubility | DMSO: >20 mg/mL |
| storage temp. | −20°C |
| SMILES string | OC(=O)C(F)(F)F.COC(=O)[C@H](CC(C)C)NC(=O)c1ccc(NC[C@@H](N)CS)cc1-c2cccc3ccccc23 |
| InChI | 1S/C27H33N3O3S.C2HF3O2/c1-17(2)13-25(27(32)33-3)30-26(31)23-12-11-20(29-15-19(28)16-34)14-24(23)22-10-6-8-18-7-4-5-9-21(18)22;3-2(4,5)1(6)7/h4-12,14,17,19,25,29,34H,13,15-16,28H2,1-3H3,(H,30,31);(H,6,7)/t19-,25+;/m1./s1 |
| InChI key | WALKWJPZELDSKT-UFABNHQSSA-N |
| Gene Information | human ... PGGT1B(5229) |
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¥ 12156.68
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¥ 9737.84
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¥ 2151.46
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