- 商品介绍
- 规格参数
- 包装参数
Biochem/physiol Actions
AMG PERK 44 (AMG44) is an orally active (F = 46% (mouse) & 55% (rat) post 2.5 mg/kg po.), active site-targeing, potent and highly selective PERK (EIF2AK3) inhibitor (IC50 = 6 nM; GCN2 IC50 = 7.3 μM, b-Raf IC50 >1 μM, <65% inhibition at 1 μM against 387 kinases). AMG44 inhibits cellular PERK autophosphorylation (pT980 IC50 = 84 nM; HT1080 T-REx-PERK-FLAG transfectants) and ER stress-induced bulk protein synthesis (IC50 = 400 nM; U2OS), as well as PERK pT980 in HT1080 Matrigel plug implant in mice in vivo (ED50 = 3 mg/kg & ED90 = 60 mg/kg 4 hr post po.).
Orally active, potent and highly selective tool compound for probing PERK (EIF2AK3) pathway both in vitro and in vivo.
| Quality Segment | 100 |
| assay | ≥98% (HPLC) |
| form | powder |
| color | white to beige |
| solubility | DMSO: 2 mg/mL, clear |
| storage temp. | −20°C |
| SMILES string | O=C1N(N(C(C2=CC=CC=C2)=C1C(C3=CC=C(C(C4=CC=C5N=C(C=CC5=C4)C)=C3N)C)=O)C)C6=CC=CC=C6.[xHCl] |
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¥ 1573.49
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¥ 2013.69
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NNALGENE 180透明塑料管，透明，柔软，多用，经济，内径 x 外径x壁厚，1/4 x 1/2 x 1/8，英寸，每箱数量50，50/箱，8000-0080，Thermofisher，赛默飞世尔询价
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¥ 3662.39
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¥ 70526.15
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