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Biochem/physiol Actions
D5D-IN-326 (Compound-326) is an orally available, potent and selective inhibitor of delta-5 desaturase (D5D) that reduces insulin resistance and body weight in a high-fat diet-induced obese mice. It appears that D5D-IN-326 significantly inhibits the progression of atherosclerosis in the aorta of western-diet fed ApoE knockout (KO) mice. It is called Compound-326 in recent J Pharmacol Exp Ther. 2019 Nov;371(2):290-298. (PMID: 31488602) paper.
orally available, potent and selective inhibitor of delta-5 desaturase (D5D)
| Quality Level | 100 |
| assay | ≥98% (HPLC) |
| form | powder |
| color | white to beige |
| solubility | DMSO: 2 mg/mL, clear |
| storage temp. | 2-8°C |
| SMILES string | FC(F)(F)C(F)(F)COc1[n]([c](c3c([nH]c(c3)O)n1)=O)c2ccc(cc2)OCC(F)(F)F |
| InChI | 1S/C17H11F8N3O4/c18-15(19,17(23,24)25)6-32-14-27-12-10(5-11(29)26-12)13(30)28(14)8-1-3-9(4-2-8)31-7-16(20,21)22/h1-5,26,29H,6-7H2 |
| InChI key | VKDOANVHEBFXOC-UHFFFAOYSA-N |
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