- 商品介绍
- 规格参数
- 包装参数
General description
A cell-permeable and reversible inhibitor of protein kinase C (PKC; IC50 = 12 µM) and stimulates Src kinase activity. Useful for inhibiting cell surface expression of selectins that promote adhesion of leukocytes or tumor cells to platelets and endothelial cells. Induces apoptosis in human leukemia HL-60 cells. An inhibitor of sphingosine kinase.
Biochem/physiol Actions
Cell permeable: yes
Primary Target
PKC
Product does not compete with ATP.
Reversible: yes
Target IC50: 12 µM against PKC
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 weeks at -20°C.
Other Notes
Cuvillier, O., et al. 1996. Nature381, 800.
Ohta, H., et al. 1995. Cancer Res.55, 691.
Kimura, S., et al. 1992. Biochem. Pharmacol.44, 1585.
Hanada, K., et al. 1991. Biochemistry30, 11682.
Igarashi, Y., et al. 1990. J. Biol. Chem.265, 5385.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Irritant (B)
| Quality Segment | 100 |
| assay | ≥98% (TLC) |
| form | oil (Clear),waxy solid |
| manufacturer/tradename | Calbiochem® |
| storage condition | OK to freeze |
| solubility | DMSO: 5 mg/mL,ethanol: soluble,methanol: soluble |
| shipped in | ambient |
| storage temp. | −20°C |
| SMILES string | N([C@H]([C@H](O)\C=C\CCCCCCCCCCCCC)CO)(C)C |
| InChI | 1S/C20H41NO2/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-20(23)19(18-22)21(2)3/h16-17,19-20,22-23H,4-15,18H2,1-3H3/b17-16+/t19-,20+/m0/s1 |
| InChI key | YRXOQXUDKDCXME-YIVRLKKSSA-N |
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¥ 2019.57
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¥ 5887.85
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¥ 3152.47
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¥ 5167.58
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¥ 3290.05
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¥ 4897.21
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¥ 4404.38
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