Cyclo(Arg-Gly-Asp-D-Phe-Val),1MG,182015-1MGCN,Sigma

销售价: ¥ 2301.17 / 件
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订货号 0BW1898
品牌型号 Sigma 182015-1MGCN
货期 询货期
最小订货量 1件
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产品介绍 Product Description

General description

Potent inhibitor of cell adhesion. Inhibits tumor cell adhesion to laminin and vitronectin substrates. In vivo investigations in rats showed it to be useful in the amelioration of ischemic acute renal failure in rats. Also inhibits tubular obstruction by preventing cell-cell adhesion. Inhibits the redistribution of c-Src into focal adhesions, thereby leading to impaired MAP Kinase activation.


Biochem/physiol Actions

Cell permeable: no
Primary Target
inhibits tumor cell adhesion to laminin and vitronectin substrates
Product does not compete with ATP.
Reversible: no


Other Notes

Shono, T., et al. 2001. Exp. Cell Res.268, 169.
Matsuno, H., et al. 1994. Circulation 90, 2203.
Noiri, E., et al. 1994. Kidney Int. 46, 1050.
Gurrath, M., et al. 1992. Eur. J. Biochem. 210, 911.


Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany


Disclaimer

Toxicity: Standard Handling (A)


技术参数 Specifications
Quality Segment100
assay≥95% (HPLC)
formsolid
manufacturer/tradenameCalbiochem®
storage conditionOK to freeze,desiccated (hygroscopic)
color white
solubility1 N acetic acid: 5 mg/mL
shipped inambient
storage temp.−20°C
长度(mm)
宽度(mm)
高度(mm)
重量(kg)
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