- 商品介绍
- 规格参数
- 包装参数
General description
Anti-Histone Deacetylase 11 (HDAC11) is developed in rabbit using a synthetic peptide corresponding to amino acid residues 2-16 of human HDAC11 with an N-terminal added cysteine, conjugated to KLH, as immunogen. Histone deacetylase 11 (HDAC11) belongs to the class IV member of the histone deacetylase (HDAC) family. It is mainly expressed in brain, heart, skeletal muscle, kidney, testis, immune cells and cancer cells. HDAC11 has a molecular weight of 39 kDa. The protein consists of one catalytic domain and is found in a complex with HDAC6. This gene is mapped to human chromosome 3p25.
Immunogen
synthetic peptide corresponding to amino acids 2-16 of human HDAC11 with an N-terminal added cysteine, conjugated to KLH. The corresponding sequence differs by three amino acids in both rat and mouse HDAC11.
Application
Anti-Histone Deacetylase 11 (HDAC11) antibody produced in rabbit has been used in chromatin immunoprecipitation (ChIP) and western blotting analysis.
Biochem/physiol Actions
Histone acetylation is a dynamic process whose levels are determined by the net activities of HATs and the competing enzymes histone deacetylases (HDACs). Histone Deacetylase 11 (HDAC11) modulates immune activation and tumorigenesis. It negatively controls the synthesis of interleukin-10 (IL-10) in antigen-presenting cells (APCs). It also modulates type I interferon (IFN) signalling.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
| biological source | rabbit |
| Quality Level | 200 |
| conjugate | unconjugated |
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone | polyclonal |
| form | buffered aqueous solution |
| mol wt | antigen ~39 kDa |
| species reactivity | mouse, human |
| concentration | ~1 mg/mL |
| technique(s) | western blot (chemiluminescent): 0.5-1 μg/mL using extracts of mouse brain,western blot (chemiluminescent): 4-6 μg/mL using nuclear extracts of HeLa cells. |
| UniProt accession no. | Q96DB2 |
| shipped in | dry ice |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| Gene Information | human ... HDAC11(79885) mouse ... Hdac11(232232) rat ... Hdac11(297453) |
| 长度(mm) | |
| 宽度(mm) | |
| 高度(mm) | |
| 重量(kg) |
-
¥ 12156.68
-
询价
-
¥ 3152.47
-
询价
-
¥ 5725.45
-
询价
-
询价
-
¥ 1509.00
-
¥ 1156.91
-
¥ 5061.38
-
¥ 1351.48
-
¥ 954.17
-
¥ 2888.88
-
¥ 5990.26
-
¥ 2754.43
-
¥ 64659.66
-
¥ 145427.01
-
询价
-
¥ 58855.47
-
询价
微信小程序
7X24小时在线咨询