Glucose-6-phosphate Isomerase human,1000UNITS,SAE0005-1000UN,Sigma

销售价: ¥ 3887.18 / 件
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订货号 0BQ8855
品牌型号 Sigma SAE0005-1000UN
货期 询货期
最小订货量 1件
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产品介绍 Product Description

General description

C-terminal histidine-tagged


Biochem/physiol Actions

Glucose-6-phosphate isomerase (GPI) is a homodimeric enzyme ubiquitously present in most organisms. GPI catalyzes the interconversion between glucose-6-phosphate and fructose-6-hosphate, the second step of the glycolytic pathway. In mammals, Glucose-6-phosphate isomerase also acts as an autocrine motility factor (AMF), a neuroleukin, and a maturation factor. GPI deficiency is the second most common erythroenzymopathy of glycolytic enzymes after pyruvate kinase deficiency. Inherited deficiency of the enzymatic activity of GPI causes hereditary nonspherocytic hemolytic anemia (HNSHA) in humans, a severe deficiency that can be associated with hydrops fetalis (a-thalassaemia), immediate neonatal death, and neurological impairment.


Physical form

Supplied as a solution in 50 mM Tris-HCl pH 7.5, and 50% glycerol


Other Notes

One unit will convert 1.0 mmole of D-fructose 6-phosphate to D-glucose 6-phosphate per inute at pH 7.4 at 25 °C.


技术参数 Specifications
recombinantexpressed in E. coli
Quality Segment200
assay≥95% (SDS-PAGE)
specific activity≥200 units/mg protein
storage temp.−20°C
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