中性粒细胞弹性蛋白酶抗体，兔单克隆，100UL，SAB5500151-100UL，Sigma 供应商、价格、厂家、报价、规格参数

产品介绍 Product Description

General description

Neutrophil elastase (NE) is a monomeric protein, encoded by the gene mapped to human chromosome 19p13.3. The protein has a molecular mass of 25 kDa and is mainly present in the neutrophil granules (located in the neutrophil cytoplasm).
Neutrophil elastase is a serine proteinase synthesized by promyelocytes and promonocytes. It is secreted by neutrophils to degrade extracellular matrix, and to destroy bacteria. It is used as a marker for myeloid leukemia cells.

Immunogen

Synthetic peptide from human neutrophil elastase protein.

Biochem/physiol Actions

Neutrophil elastase (NE) is a key driver of inflammation in many cardiopulmonary and systemic inflammatory and autoimmune conditions. The encoded protein catalyzes the cleavage of tyrosyl-tRNA synthetase to produce cytokine domains that stimulates neutrophil chemotaxis. In addition, NE also facilitates the secretion of the neutrophil chemoattractant, interleukin-8 from endothelial cells.

Features and Benefits

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Physical form

0.1 ml rabbit monoclonal antibody purified by protein A/G in PBS/1% BSA buffer pH 7.6 with less than 0.1% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

技术参数 Specifications

biological source	rabbit
Quality Segment	100
recombinant	expressed in proprietary host
conjugate	unconjugated
antibody form	affinity isolated antibody
antibody product type	primary antibodies
clone	SP203, monoclonal
species reactivity	human (tested)
technique(s)	immunohistochemistry: 1:100
isotype	IgG
UniProt accession no.	P08246
shipped in	wet ice
storage temp.	2-8°C
target post-translational modification	unmodified
Gene Information	human ... ELANE(1991)

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