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General description
Matrilin-3 (MATN3) is a major component of the extracellular matrix of cartilage. MATNs are a family of non-collagenous extracellular matrix (ECM) proteins consisting of four known members that have been proposed to play key roles in modulating cellular phenotypes during chondrogenesis of mesenchymal stem cells (MSCs). MATN1 and MATN3 are expressed specifically in cartilage and are among the most up-regulated ECM proteins during chondrogenesis. MATN3 is composed of a single N-terminal von Willebrand Factor A (vWFA) domain followed by four epidermal growth factor (EGF) repeats and a coiled-coil domain whereas MATN1 is composed of two vWFA domains separated by one EGF-like domain. MATN1 or MATN3 may play a role in modulating chondrogenesis during the chondrocyte differentiation process. Mutations of this gene have been associated with variety of inherited chondrodysplasias. Recent studies show that aberrant expression and processing of MATN3 are hallmarks of conventional cartilaginous neoplasms.
~52 kDa observed. Uncharacterized bands may be observed in some lysate(s).
Immunogen
KLH-conjugated synthetic peptide corresponding to the C-terminus of human MATN3.
Application
Detect MATN3 using this Anti-MATN3 Antibody validated for use in western blotting & ICC.
Immunocytochemistry Analysis: 5 μg/mL from a representative lot detected MATN3 in NIH/3T3 cells.
Analysis Note
Evaluated by Western Blotting in NIH/3T3 cell lysate.
Western Blotting Analysis: 1 μg/mL of this antibody detected MATN3 in NIH/3T3 cell lysate.
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
| biological source | rabbit |
| Quality Segment | 100 |
| conjugate | unconjugated |
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone | polyclonal |
| purified by | affinity chromatography |
| species reactivity | mouse |
| technique(s) | immunocytochemistry: suitable,western blot: suitable |
| UniProt accession no. | O15232 |
| shipped in | wet ice |
| target post-translational modification | unmodified |
| Gene Information | mouse ... Matn3(17182) |
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