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General description
HDAC11 is responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation is a marker for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. The predominantly nuclear HDAC11, which interacts with HDAC6, is weakly expressed in most tissues, and strongly expressed in brain, heart, skeletal muscle, kidney and testis. Its activity is inhibited by trapoxin, a known histone deacetylase inhibitor.
~40 kDa
Immunogen
Epitope: N-terminus
The immunogen was a KLH-conjugated synthetic peptide corresponding the N-terminal region of human HDAC11.
Application
ELISA:
This antibody has been shown by an outside laboratory to be suitable for ELISA (1:1000).
Immunohistochemistry:
This antibody has been shown by an outside laboratory to be suitable for histochemistry using formalin fixed, paraffin embedded human hepatocarcinoma tissue (1:50-1:100).
Research Category
Epigenetics & Nuclear Function
Research Sub Category
Cell Cycle, DNA Replication & Repair
Use Anti-HDAC11 Antibody (Rabbit Polyclonal Antibody) validated in WB, ELISA, IHC to detect HDAC11 also known as histone deacetylase 11.
Biochem/physiol Actions
Not tested in other species.
This antibody recognizes HDAC11.
Physical form
Format: Purified
Protein G Chromatography
Purified rabbit polyclonal in buffer containing 0.09% NaN3.
Preparation Note
Stable for 6 months at 2-8°C from date of receipt. For long term storage, store at -20ºC. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Analysis Note
Control
Mouse Brain cell lysate
Western Blot Analysis:
Detection of HDAC11 in 10 µg of Mouse Brain lysate by Western blot analysis.
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
| biological source | rabbit |
| Quality Segment | 100 |
| conjugate | unconjugated |
| antibody form | purified antibody |
| antibody product type | primary antibodies |
| clone | polyclonal |
| species reactivity | human, mouse |
| technique(s) | ELISA: suitable,immunohistochemistry: suitable,western blot: suitable |
| NCBI accession no. | NP_079103 |
| UniProt accession no. | Q96DB2 |
| shipped in | wet ice |
| target post-translational modification | unmodified |
| Gene Information | human ... HDAC11(79885) mouse ... Hdac11(232232) |
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