- 商品介绍
- 规格参数
- 包装参数
Application
SB-408124 was used to block orexin A-mediated cardiovascular effects in rats. It was used to study block the increase of endogenous glucose production mediated by bicuculline in rats.
Biochem/physiol Actions
SB 408124 is an OX1 orexin receptor antagonist.
SB-408124 blocks the orexin type 1 receptor that stimulates the production of stress hormone in hypothalamus. It blocks orexin A-induced increase in arterial pressure and elevation of heart rate in rats. SB-408124 modulates phrenic nerve activity that is important in respiration.
Features and Benefits
This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
Legal Information
Sold for research purposes under agreement from GlaxoSmithKline
| Quality Segment | 100 |
| assay | ≥98% (HPLC) |
| form | solid |
| color | off-white |
| solubility | DMSO: >10 mg/mL |
| originator | GlaxoSmithKline |
| storage temp. | 2-8°C |
| SMILES string | CN(C)c1ccc(NC(=O)Nc2cc(C)nc3c(F)cc(F)cc23)cc1 |
| InChI | 1S/C19H18F2N4O/c1-11-8-17(15-9-12(20)10-16(21)18(15)22-11)24-19(26)23-13-4-6-14(7-5-13)25(2)3/h4-10H,1-3H3,(H2,22,23,24,26) |
| InChI key | JTARFZSNUAGHRB-UHFFFAOYSA-N |
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